George Hotz | Programming | reverse engineering the coronavirus #lockdown part3 | COVID-19

Key Takeaways

hello hello hello yeah we're live live boys all right so to recap things that we've learned the coronavirus is just sars that's something that we learned what else did we learn that's all we learned no actually if you look behind me you see that i went to the supermarket and i bought two weeks of food um yeah yeah because i did some i did some models this morning i mean like really dumb stuff i kind of just like did this and woke up so this is the month of april and this is my model is very very crude but this is the number of people uh infected in america at the current rate so as you can see around like april 15th well um so i did this math and then i'm like damn i should go to the supermarket so i went to the supermarket because for this part of the curve you're going to want to keep your doors locked and you're going to want to uh have a good source of food and water um here's when the m16s come out you know the m16s we always talk about uh what's this one see this link but does this let you do any like i haven't found a is there a good website that lets you do like projection oh look we stopped the coronavirus in its tracks this plague.com too um doesn't look like a curve it's just new york okay that's the first day it looks like it's leveling off but you know that can all be very very suspicious george you look jewish with you on your team um i am circumcised and i do hear that that's the most painful part of uh countries are already hitting the max carrying capacity okay well that's very optimistic of you i think italy is the highest at point one um if we look at the us that sure looks like an exponential curve to me can i zoom in on that uh you know we really try to stay away from news and we try to only focus on data uh i just downloaded i downloaded this data from plague.com so this is just um this is the data as graphed on days of march uh zero is actually uh um the last day of february so if you look at that i mean you can say like okay that doesn't look like a curve but not with the log on that and uh i mean that fits pretty well guys um information is beautiful these are nice graphs now but what i really want to see is uh is projections are there any good websites that have projections yo look into msm and how it inhibits what's this is this part of coronavirus let's check my docs here i don't have any nlrp i'm confused by this but yeah no i just i just downloaded this from from plague.com and this is just the the number of uh confirmed cases in the united states if you guys haven't seen plague.com this is a good way to watch this oh my god it's even higher now 33 yeah 43.6 fits the curve perfectly see that's that's the real exponential there he's like 30 32. i'm i'm 30. uh i mean the interesting thing so the hospitalizations i wish i could just filter out every news story um this doesn't tell me what i want twelve percent have been hospitalized um but it doesn't matter that much what age you are right for whether you get hospitalized the icu it starts to matter a lot more if you're if you're older you're a lot more likely to end up in the icu and you're a lot more likely to uh to die instead of benchmarking singapore well and those countries have really i don't know what singapore did specifically but south korea took well not quite china's approach but um you know they uh they tracked people's cell phones i mean they they enabled the batman device like that's probably worth it uh if our government was that confident patient medical data can it be possible that china all of a sudden didn't report new cases let me show you why china didn't report your cases here's my theory about that um i don't think uh slaves if you guys don't remember codex i love this website scott alexander's a genius returning home with your disease will not make your planned parents pleased infecting mom and dad proves you have no conscience those who don't report their fever are class enemies hiding among the people save pennies not wearing a mask spend a fortune getting treatment on your sick bed a surgical mask or a breathing tube it's your call right so i mean yeah china has no new cases oh this is a nice data set id oh sequins available whoa wired noise we speak english in this channel i'm going to refresh twitch so i can see the viewer count 321 all right cool i think it's time to get started for today first we need some tea ah i like corn as well um oh the csv for that date is at the bottom of the page perfect just something good to grab for later you never know when you're gonna need data well i mean yeah it's you know more people have died than 9 11. 9 11 was was an attack on u.s soil though and i think that's why you know it's so it lives in wuhan oh it's a little data china was not behind the attack guys um though i mean it's interesting thinking about china originally really downplayed this and then they went they did like a complete 180 from downplaying it to you know those propaganda posters i mean i think this is what you get if you actually get a smart government that cares most of all about economic growth and this isn't necessarily the wrong choice you know people in america are always like but you've got to think of the people's lives the economy be damned i mean if we're using the excess economy growth for you know bullshit uh maybe this is true but the standard of living in china has risen so rapidly china has pulled more people out of global poverty in the last 30 years through their economic growth in any other country um you know china was it was a 30 years ago let's see maybe maybe 40 years ago right 40 years ago shenzhen was a fishing village now shenzhen is a 20 million person crazy city with some of the sickest malls in life uh do you say india up next i've never been to india and maybe i'll change my mind if i go but um i'll believe it when i say it what can someone lost their job do online to make money capitalist utopian communist dreams take who thinks a communist state is a dream state i don't know what kind of dreams you're having all right let's get back to work um so here is a sars cup 2 ncbi i found that other remember that thing that i like lost i found it again this here down here so these are those uh this is what we're looking at this is the coronavirus i mean it's nice because this one breaks down orf1ab uh anarcho-communism yo i wanna date once and this girl told me she was an anarchist and i was like oh that's interesting so i went back to my car and i got my gun out of the glove compartment and i put it in her face and i told her you're my slave and this worked you know for about two minutes until the bartender pulls out a shotgun he said you know what you guys are both my slaves and this worked for about 10 minutes until the army showed up outside with some tanks pointed them at the bar and said you are all my slaves and then we're kind of back to you know where we started uh so that's what i think of anarchy yeah the military oh kova dash githubaio has projections so size thank you for subscribing uh nah the girl was kind of weird she brought her dog to the bar um oh projections now we're talking wait can i project further wait but i want to go further can i not go further how do i project further anyway yeah for the last couple weeks uh it's been very logarithmic what do i think about how italy is handling this story you guys kept asking me the question like when is this all gonna be over when is this all gonna be over and i was just like i don't know um you know when i started these streams i didn't take coronavirus very seriously um and now that i've learned that well it's you know sars i've taken a little bit more seriously uh is there any way to go further with the projections this is probably open source now um is the source of this somewhere let me go out further with this ah there we go and then can i predict more this is the source code i'll make a small feed guys the local dash app some social shaming for 10 vis responses look how biased as science is this what the people can't handle the truth so probably all cool things to learn about there's so many like incredible python packages out there now stats models i don't know why my donation never showed up did it not go i don't i didn't check but i don't think the wallet i have on my phone supports segwit addresses it's the bitcoin cash wallet and i have the private key i have the private unions like oh let's steal his crypto i got like 600 bucks social blocks has been extended in the netherlands yeah the 21 is probably gone um all right what is this doing historical replay we're getting distracted i promise we'll get to do reverse engineering in a little bit what is this doing oh python package for molecular dynamics simulations now we're talking mdanalysis.org that is where we were going to go well actually i just googled it and found it we did say we were going to try some molecular dynamics today i'll let that run for a bit maybe it'll eventually do something all right don't ask me how i studied to code don't ask me about why you got banned from discord uh as rule i will say this the people that you know with flu symptoms probably have the flu the flu affects millions of people every year the flu didn't stop just because there's coronavirus um okay you know the amount of people who are a little bit sick now and probably like i'm sure i have the coronavirus i'm sure i have it well i mean do you i have zeesh because uh it came with the mac [Music] i'm gonna turn the lights off all right guys let me show you what what you bought i got prepper stuff today check out what's in these bags check out some of these beds you know no one knows where i live in a couple weeks everyone's going to be trying to try to rob me of these potatoes man oh you know what i could really go for some shells of white cheddar macaroni and cheese right now oh this looks sick right all right we're just gonna cook this up who's knows it for roo yeah no i'm ready for the m16 man testing my lock out we're good all right i don't know what this is doing i can use the potato skins as tp i have no idea why people are buying i bought two weeks of food and i'm gonna start eating it now oh it's like doing the predictions of all of them should we spend time trying to make this work get all data oh exactly wow these people went really overboard with like this i don't know i mean this this model seems way too complicated it seems like it just runs too slowly when like just fitting a line to the log it'd probably be pretty good no okay make figures do you guys want to see me do this or do you want to get back to reverse engineering you guys can vote in the comments what does yes mean oh no what reverse yes isn't doing what i'm doing i don't know the vote seems 50 50. or should we make macaroni and cheese y'all making the macaroni and cheese in a pot cooking it up [Music] bringing more water that thing around tweet around oh sweet okay united states where did they get this number from that like didn't go up that day okay we're gonna spend a few minutes trying to fix this and if we can't fix it we can't fix it we just want a model for the united states that extends past download the data we only model the active cases wow wow does that work when will coronavirus 2 come out well this is already v2 actually um you know they used to have a name for it used to be called sars but i think they figured you know oh i said it's not so this is sars detail so does this have the predictions or does it need that stuff that i commented out sweet it has predictions all right let's go into modeling uh don't show predictions more than 10 days ago how do i make the prediction longer you word immunity is like the biggest crowd source uh maybe this is it yeah prediction dates let's do plus 30 there oh this didn't actually work at all um still is calling historical replay first with ramp windows so that thing that was actually taking forever to run i think it was running on every country and that's why it was taking so long we of course only care about america so if we could just make it work for america i'm happy i don't get it this is stupid it already writes the stuff there i don't know if it rewrites it again but also australia no no we leave america here you can you can follow my instructions you can do a first try if we want to know if we want to know when is the shit hits the fan date is this irresponsible graph making what uh oh yeah so i think there's a problem i think we can't even see it gotta go to log can we see it no no no okay all right so yeah oh it doesn't automatically scale at some point anymore sweet okay so we're here now oh this is this is perfect this is exactly what i was looking for um so yeah we're we're here right now and if we continue on the current trajectory uh we'll hit a million cases in about two weeks and we'll hit a hundred million cases about uh two weeks after that it's march 23rd so let's see april 23rd yeah april 23rd we now and this is of course going off of confirmed cases it seems like 50 of people don't have symptoms uh so um yeah you know what's you once you look at that graph of it and you're like holy shit man um society was nice while it lasted uh the three blue one brown video is very good um i'd bet against the grafton uh the three blue one brown video goes into the fact that everything actually is a sigmoid so you're gonna reach some point um so it's interesting also that we have uh the social isolation and we don't see this at all we don't see it reflected anywhere which is probably because it's too soon to see it because of the incubation period [Applause] who's getting arrested for spreading rumors oh yeah well i was in china um this is america you can uh say whatever you want to predict humanity's workout no we're not uh we're not we're not reverse engineering yet we're just extrapolating out so we'll see um the [Music] i think the population with the highest penetration right now is italy's and it's at 0.1 percent 1.1 percent of america would be uh 300 million 300 000 people so yeah you know what um if we hit a million people by april 5th uh everybody uh run for shelter um don't run for shelter calmly walk and shelter in place for the next two weeks uh can we see the italy graph yeah it should work huh so some of italy's effects appear to have been working i mean yeah the united states will pass italy at some point there's also it says it's just active cases i mean the united states will obviously pass italy at some point because italy has 60 million people and we have uh 300. i mean the question really is what percent of the population gets this disease i think the best uh way to estimate this what percent of the golden princess cruise ship number of cases diamond princess um can i get real data that's not news can someone find the the cruise ship data uh i mean yeah the cruise ships recycle the air but you know we're kind of all on a cruise ship right uh yo it must have been terrible man you get free free carnival cruises for life or something check the s-i-r model analysis of stars yeah check this out hmm oh this one rarely returns new sites sweet duckduckgo returns news sites as well which is kind of upsetting um okay but uh god this is whenever i look at these decentralized projects it's like this is terrible this is terrible i don't want to have to pick one of these i don't know what any of these things stand for why don't you start with that i get that it respects my privacy and all i don't care anybody who wants can see my searches the only thing is i don't want shitty news um diamond princess number of coping faces great okay cruise ships this is a table from the cdc okay ah yeah yeah this is nice oh look they did a good job this link is it fake or is it really live um we can yeah i have seen the new york times one what do you mean is it fake no it's not fake what do you think is fake okay so the diamond princess cruise ship had 30 i mean this is simple math now let's just let's just look at percentages right so assume that like the cruise ship fully circulated the air and there were 711 cases and i've heard that uh half of them are asymptomatic oh come on of course we want python 3. okay so 20 so about if we assume that they're not testing people without symptoms then 10 of people look like they're going to get the disease assuming that this stuff doesn't work so 10 of america is 30 million yeah okay uh i don't think the noise thing had anything to do with me yesterday there's people upstairs banging shit uh so 300k dead um if you're going with a 10 mortality which seems high uh and not no not 300k with the virus it seems like 3 million with the virus well so 6 million with no no 60 million with the virus 30 million that show symptoms and then of those uh seems like five percent uh uh death rate's about five percent if you're going off the sars it's like a million people um bro i don't think the holocaust was fake my shelter a little crunchy we're gonna put on a lovely song and then we're gonna get to reverse engineer whoever's listening to music you don't like the music billion bitcoins uh well you know good thing this stream's not a democracy what did young lacuna beside everyone should switch to pie torch yeah that seems right so basically yeah i mean this year just um everyone's uh yeah sometimes i let the people vote so they think it's a democracy i kind of like bright eyes um no i think jonathan's right but exactly it's like a real democracy nose for attitude understands what's up [Music] point of no return you mean immortal technique if you guys really want a mindful dance with the devil all right let's get back into this with a little bit of just improving our documentation and then so for reference the issues that we're working on you can find them here in the readme oh actually i should pull some updates so we have two open questions um how is orf 1ab cleaved into polypeptides can we predict this from the sequence let's look into that question a bit and the other question we're going to look into is which protein is the immune system responding to you know you think 20 is not right as the upper bound for infection the cdc have that quite nice graph right like i mean it's starting to taper off i don't know maybe the upper bound is a little bit higher could someone link zeus to repo especially if he subscribes so one and a half americans dead i think that's a pessimistic no no it's possible it's pessimistic and we're going to see we're going to find out in the next few weeks whether the like um no i think orf is cleaving i think we're going to find out in the next couple weeks how well the um like the social distancing stuff is is working out we're going to get lots of really cool experiments across all the countries no and we're not at the forefront of this italy right now is at point one percent um but it is actually it is interesting dude someone did link that italy data saying that it's it's going down um is plague.com open source because i would love to submit a pull request to be able to switch this to graph to log mode because like you can't see anything unless it's in log mode we have my viewer all right the new york times one is good making my computer lag okay this is making my computer lag this is cool i'll check it out later when i'm not streaming um do i even still have my i love this guy we can look at italy because italy actually does appear to be tapering off even if we go out further well i mean yeah it's really not taking into account the second order effects this is also only active cases so one percent of italy is uh six hundred thousand yeah i haven't even talked about case fatality rates i just don't really know um i mean it depends on so many factors you know when you look at when you look at when you look at germany um you're like how does germany not have any deaths i mean they don't have that many recovered either so maybe they're just early like they don't seem that much earlier than like spain which has like 20x adapts but out now i'm heavy into speculation realm we're done with that for now um stop saying racist stuff bench ai don't tolerate any racism around here this is a no racism place yeah germany doesn't have any deaths no racism that's right that's right okay i don't want to let this turn into a general coronavirus speculation discussion i will just say i bought two weeks of food this morning i recommend everyone else do the same because work case you'll have lots of macaroni and cheese to eat if you don't have two weeks of food in your house already it's the kind of thing that i should be more serious about i mean i just did the math on calories all right all right well okay we can check this out too so this is not that bad the first milder outbreak protected against the sars back fitting data okay so the cleaving i think that the cleaving is happening with these protein aces former nsp1 conserved domains like protease there's good stuff on this website so it's this responsible for the cleavage located at the end terminus of the replica poly protein so the replicase polyprotein is ortho1a and or1b participates together with nsp for let's understand what a pep hang is [Music] oh i was listening to some i was listening to some stick chip to him before um no no it was i saw him in hacker news i forgot what it was called um yeah yeah this guy he just plagiarized chiptunes [Music] let's look into molecular dynamics while we listen to this because we can't think while we listen to this i love underwear girls inside the pants i listen to that in high school it's kind of shifted open my eyes [Music] [Music] girl guy thank you for subscribing do [Music] oh you want a song like underwear goes inside the pants i will listen to it on stream i know i know one other song kind of like it um what's it called oh i can't even think of the guy nomads um no it's an it's an old song it's a portland guy um nomads and it's it's it's a classical piano beat um we're gonna find this now because it's gonna drive me crazy if we don't uh actually if we go to my youtube i used the i liked it so much that i used the the song in this pick me apart yeah um somebody stole my car radio and now i just sit in silence this is all right um also most of it's terrible but other side by macklemore defenses remix shit got me into sipping lean man you know i listened to that i'm like damn a sibling it's a little bow burner mask yeah all right that really switched up the vibe hard [Music] [Music] what they used to simulate this it's just the analysis so it must have [Music] been [Music] [Music] [Music] so [Music] so 20 000 atoms all right wait there was a network there or what is my stream online uh my twitch glitched out uh this is the github for plague.com oh you want to add a log graph to this we could like do them a favor did someone already do it whoa this is so cool like i mean i just love to be able to is there already a way that i just don't know i want this on log all you can do is confirmed daily increase yeah so you silly fall that's really good not america um why they took log mode out why did they get rid of vlog [Music] does someone want to read the changelog and figure out why they got rid of log mr shabasaki thank you for subscribing [Music] i know east of china is a separate thing i remember that perhaps an oversight no i want to work on a qr code we're playing with uh molecular dynamics tools well so you see notice how it's md analysis is an object-oriented python library to analyze trajectories from um md and now from molecular dynamics simulations but the question is okay now how do i actually trigger a molecular dynamics simulation like what do i use for that comes with a number of real trajectories for testing grow max chronogen machine it's one of these things that's going to need like huge amounts of computers like a big cluster the good news is i have a big cluster they got rid of log because they're monitoring people visiting the site that doesn't make sense wait we back on the hype train yo the hype train's back yo i love the hype train it made me money yesterday does this one have vlog i wanna have a log scale i see that's much better i just [Music] all right things look pretty good for italy right now but we're done with this we're getting distracted we're only all about that hype train right now drogo thank you we're at the level two hype train we got a hundred percent i think we're about to get to the level three hype train choo choo uh or how to lecture for md analysis all right let's see is it long well um hello everyone um is that yo level 3 hype train we got we got four minutes to get some more subs now i don't get any more noise complaints it's just someone yelling i don't know maybe they'll get all right we're gonna watch this later it looks like gromacs is the thing to use we have excellent cuda based gpu acceleration well let me show you something i have i'm using it right now but we got a lot of those machines that come choo choo thank you for the hundred bits nacho avavin nasho boy devoid yo anyone else who subscribes right now you get a shout out you got three minutes i'll give you a shout out we're gonna go back no the claims are all fake we learned droco thank you for the bits thank you for the bits droco keeping those bits coming yeah love it love it look at them gpus man we got plenty of gpus to fire off in gromacs is this a tutorial for this namd is this a different one what is this huh solvating the protein generating a protein structure file all gems for you thank you 71 we got two minutes to get the hype train to level four and then we can give up on the hype chain if you were thinking of subscribing right now is the time right now is the time to subscribe grow max how do we put things in to grow max this growmax looks better than this one i trust this one less i mean why do i need a protein structure file i guess it's okay fine it doesn't actually fold the proteins mr zlz thank you for subscribing gold seas thank you for subscribing gold skis we're at hydrate level four so like it's gotta be someone just did this using gromacs visualizing protein soldering compacts ilya rpv thank you for subscribing can we study protein folding through molecular dynamics and simulation okay so itasca this is what this is what the guys talked about using uh with that zang website talked about using um what do i think of using ml britain x2 thank you for the for the bits first of all is structural sim templates oh it is zang lab yeah this is actually the thing that they make and they're the ones who had that who had that analysis of the uh of the coronavirus here um over here and they generated these models see i guess the estimated tm score i mean i guess if the way i test it works is it identifies yes structural templates with low meds you know biologists love to name things like this you see the stanford paper about my programming challenge no do you think the u.s is going to develop an app remember that time they tried to make a healthcare website it's not on my eyebrows is there a way to see where the virus overlaps with a bat yeah we could do that i actually have a link for that in the uh this doesn't mean it's okay like how about this i mean i don't know if i got a uh a submission of their their their test results um if they submit their test results to me i'll tell them how they did okay this doesn't work at all you can't randomly shuffle the pairs of data and take twenty percent put eighty percent of it in a training set and twenty percent of the test set the reason why is those frames that you randomly pulled out are extremely correlated with the frames in the training set that look just like it see what i'm saying you can't do that level three hype train share choo choo hype oh look at that yeah you can't do that how do they know well let's just let's just we'll write that in the readme how do the researchers know where or 1ab leaves you hear those dogs does not indicate snakes by the way i feel like i did read the comments um and someone said i got the number of base pairs of hiv wrong whoa really hiv is you can fit three hivs in one coronavirus look at this paper for how the researchers know okay oh i'll put this link in here did i do my markdown right one i don't know why that took forever by two viral system and i think i saw the other one in there too yeah so or three and or five are cleaving it very cool are important targets for the development event oh just if you prevent the cleaving oh that's clever you chicago where fun goes to die i believe in that school it doesn't matter if it stars or oh i believe in it even more if it's about sars okay a lot of the science that's come out about coronavirus i think is kind of crap um because you know you want to get famous publish your chrome environment but this is very cool and considering stars and chromosomes want to get popular stream coronavir stuff yeah right um oh okay look you see i think that in sars they're calling it different things let me just check here let me check in the in the uh in this structure because i might want to change my naming to match ncsp yeah so they're calling this one thirteen we might wanna change my naming ncsp 10. where's that's 12 where is oh 11 is like hidden down there oh okay 13 amino acids just to make my numbering match the other peoples look how i'm using their language 13aa that's 10. someone found out that i put two sevens in the sars and they submitted a pull request for it it's pretty funny i typed seven twice okay now my uh my stuff matches there so it's easier to understand okay frame shift we learned a little bit about these wow which numbers which 4005. that can't be right what do those locations mean those just can't be right because i'm already like 12k in the virus you know zoom in too much zoom yeah it's like right around it's right around that that missing point pump this link computing the opening of that spike yeah we've learned all about this yes there's yeah there's two um as far as to spike in motion yeah look at that what did they use for this yeah oh wow they they have it cool we modified this bond orders and the sugars we use the a-wrap oh i see what they did so they didn't like this isn't like molecular dynamics or anything they just um they they you can download both the proteins actually have them both uh both here so you have the open state and the closed state um so they they just built something to to go between them uh wait hang on i gotta i gotta do something for work i'm just gonna do it right over here um so you guys can't see it i'm sorry uh you know what you guys can see it's not secret what's your question okay someone linked me the graph we'd use to see the us numbers um so i modified this covid dashboard thing probably if you just search for covet dashboard it's probably good um the best accuracy on the comma ai test set uh forget the virus stay home i mean there's an argument to be made that if you're going to get it you want to get it right now before you know all the hospitals are really overloaded um you had to get like a month ago that was really the time to get it imagine how good the people were recovered from well actually let's look that up community the stars specific igg antibody i've seen this like reference before i don't really know what it is immunoglobulin g whoa i mean is this like a what's the dna sequence of this thing how many base pairs is this thing looks simple i don't know what heavy constant gamma one is no i don't think this is right i don't know let's not get too distracted um free full text how do i get free full text i take this i go to scihub.com.tw i take this so i put that in there and i get free text is it a bad time to eat meat no top right of pup bed oh sweet despite protein and the nuclear capsid protein they spelled nucleocapsid wrong concerns me um contribute down to the antibody production oh okay i mean that that kind of gets it like one of those questions that we were uh we were asking let's just do a citation here we'll spell it right let me actually not just let me actually write a tiny documentation for this nsp3 and nsp5 is what they were saying right uses the 3cl pro which is nsp5 and a papine-like protease which is nsp3 it's interesting that like the way that it's cut up is actually inside of the protein contribute dominantly the antibody production during the cost of the disease spike protein especially the ace2 binding region is capable of producing neutralizing antibody five major they spell nuclear caps that are wrong there too but it is a chinese journal so you know the pattern of cytokines are all these people going back and reading the sars papers because these papers are so much better than any other coronavirus papers i've read what's this one what is this they tested the biologists the survey was negative against all of them except for one guy who got bitten by a bat i don't know about that study what are cytokines so i i mean you know they always talk about a cytokine storm and that's what uh hydra yeah this um this is they gave this in france uh because they think it prevents the cytokine storms is there a good video like is it one of these that's not like at a stupid high level we're immune system of pathogens and other four dots each antigen has a unique matching and all of this is no no no no no is there a good one of these can someone find it good how the immune system actually works that mentions like lymphocytes and cytokines and stuff uh viruses become more transmissible and less deadly well there's i'm reluctant to click is is this is this a rickroll link oh hey everyone on behalf of cambridge to analyze this factor by identity no no this is too long i want like one of those new youtubers like you know like like wendover and stuff like those people who make those really good explaining videos that coronavirus explaining video was very good to the right of what i clicked before [Music] [Music] hey a pathogen is a disease-causing organism there's a few examples we've shown here on the screen your body's fairly well equipped to try and deal with the pathogen does get in there we're going to discuss this in the context of some of the blood cells that are involved now you also know about red blood cells they are therefore transporting oxygen there are also the lymphocytes and phagocytes lymphocytes and phagocytes are both types of white blood cells if we have a look at what they really look like here in this dimension t lymphocytes cytokines are messenger you can see first of all this red blood cell i've highlighted one of them here but that's the one where you can see hundreds of them on the screen the lymphocyte there you can tell that the lymphocyte because it's got that really large nucleus and the phagocyte down here you can distinguish that from the lymphocytes because of the unusual shape of a nucleus and we describe this as having a lobed nucleus it has that shape because it needs to fit something inside there we'll discuss that a little bit later first lymphocytes when a pathogen enters the body it has something on it's called antigens and these antigens can be recognized by the antibodies of the right type of lymphocyte it reduces these antibodies in large numbers and when they attach to the antigen it results in the destruction of this pathogen well how exactly do they work well there's a few different methods that antibodies can use in order to destroy pathogen first of all they might cause this certain set of reactions which is going to result in the cell membrane of the pathogen makes the organ another thing it might do is it might make it easier for phagocytes to find the pathogen we'll discuss shortly how phagocytes can destroy pathogen another thing you can do is make the pathogens stick together which again makes it easier for pathogens to find them and in both them but also it prevents it from going about its daily business imagine you and a bunch of your friends are all stuck together you find it really difficult to have your lunch and things like that it's important to realize that very specific antibodies are needed for specific pathogens and since each lymphocyte makes only one type of antibody it might take quite a while for your body to find the correct lymphocytes they can produce the right antibodies to destroy the pathogen and the consequence is you might get sick in the meantime before your body actually finds the correct antibody and is able to destroy that pathogen one thing that happens is that memory cells of that lymphocyte are produced after fighting the infection some copies of this specific lymphocyte were made these specific copies are memory cells and what that means is if that pathogen is your body again it can immediately stop producing the antibodies that it needs and then it can fight off the packaging before it has time to make you sick so basically you can't get sick from that same pathogen a second time this is immunity let's look at the next type of white blood cell and these are phagocytes and they've got a very very different method of destroying pathogens first of all the pathogen enters the body and then the phagocyte recognizes it and starts to move towards it the next thing that happens is the phagocyte engulfs the pathogen it's really important to use the correct vocabulary here don't say that the phagocyte eats the pathogen that's not correct it's a very different process you're eating then what is inside of the phagocyte it gets destroyed using enzymes and finally the homeless broken down products of the of the pathogen are exited from the cell and then it's been destroyed the pathogen has been destroyed in the phagocyte and go on and engulf new cells so what about possible exam questions well one possible one is that they might give you this sort of picture showing of what blood might look like on your mind these are red blood cells these are lymphocytes and these are phagocytes and functions of each other well the first one now this is a red blood cell and it's used to carry oxygen throughout your body this is a lymphocyte and it makes antibodies it only makes a specific antibody and antibodies can do a whole bunch of things it can get things to stick together and this is phagocytes don't say that they eat pathogens they engulf them obviously blue cell you know that's responsible for transporting oxygen b is the lymphocyte and this function is to produce antibodies to help destroy pathogens and c is called a phagocyte and you might be tempted to say something like it eats pathogens but once again these don't make that mistake you cannot get them off for that you get the ghost pathogens if you do like that you get your full six marks yo i'm gonna get a degree in bio when i'm done with this i just listened man you mad bro you mad you know what bro i got a plan for you you should start your own competing coronavirus stream now that was a meme from yesterday you guys okay cytokines and t lymphocytes these are these are the these i i've seen this stuff from from uh from aids acquired immunodeficiency syndrome well that sounds terrible completely real talk guys you can now buy a test at home to test for aids and like it's not like you mail it in it's like you can just take it right there and you like mix some stuff together very chevy sure it does not give you aids no and the test is for hiv i should be specific about that aids is what hiv causes unless of course you're carrying moss then you don't believe that carrie mullis was the inventor of pcr he won the nobel prize and then went on to talk about mullis expressed disagreement with the scientific evidence supporting climate change and ozone depletion all right all right you can go either way on that the evidence that hiv causes aids and then all right then really you know and asserts his belief in astrology why do they link these together you know i do always find that it's weird um someone mentioned the uh so someone mentioned that that the holocaust was was was a hoax a couple comments back and like this very obviously isn't true but i find it funny that they're like they label like denialists right like whenever they have to label the nihilists i always wonder it does make me a little more skeptical yeah denialists right you know there's no like you know two plus two equals four denialists though you know i have a finite test guys i have a finite test so you can look up what that means you know some weird shit that i believe in but so it seems like the igg one is still produced persist for a long time while igm is expressed transiently whoa immunological epitopes in the spike protein so for reference you guys remember that this is the spike protein here we should label it with the number of base pairs or the number of amino acids i mean uh it's here 1273 amino acids and remember that it's a trimer i think i'm using the right word because like three copies of it kind of weave together quality meme bros oh so that's in sars v1 so they added they added a bunch of what's a glycolysation site whoa yo there's like a whole world of bio words no no he didn't exactly take that drug i think he i think the guy who died took we'll look it up az death chloro quinine yeah so the problem was he took chloroquine not hydrochloroquinine so it's actually really not yeah hydroxy a less toxic derivative of chloroquinine um which one is it's called like uh yeah yeah plaquemines yeah you can you can like buy this like there's people who have it you can you can like pick it up and you can go down to mexico and pick that up phospholipid bilayer we learned about that what's the book of hours i can't i can't not click that link nice book bro four regions with highly immune reactivity how do they know this based on antigenic prediction ace2 binding region is a weak antigenic determinant wait so the dna vaccine actually works there's some guys trying to make it open source uh open vaccine yeah these guys i tried to donate some bitcoin to them but they used a segwit address so my bitcoin went through all right stop spamming my immunology notes from uni i don't think you want me to open those on the stream um the dna vaccines were never approved please watch this all right make you a mod please no no no who's trolling next next trolls you know we're gonna we're gonna martial law in the chat man um that's difficult so wait when the mice are monkeys for what's that adenoviral delivery vaccine containing expressible full length of the spike gene anti-ace ii binding region activity was combination of these two bindings and antigenic determination it may be used as an antigen for asylus vaccination i mean yeah this is basically what these guys were saying and like it makes a lot of sense they had a uh they had a pdf um so let's see are they express a modified form of the spiked protein modifications to increase its stability a furin cleavage site let's understand that i'm sure i googled this yesterday and i just forget what is fearing though oh it's a ubiquitous what there's so many words um we may want to consider mutating this site oh it's modified isn't it attenuated oh it can't penetrate the transmembrane proteins but it's recognized as an antigen okay that makes sense yeah yeah the urine is on the host side okay uh yeah i'm sure that's something your body produces it's not in the thing um it's just weird that it's a ten they're not talking about attenuation they're talking about stability right like i mean i guess you wouldn't want all these spike proteins binding to your a sites but it may not matter yeah the whole sphere includes the spike yay i know this yeah okay so that makes sense so it's a fury and cleavage site but oh interesting so we should actually be able to find that oh that's a good open question find the urine cleavage site in the spike glycoprotein you know these things could just be called like any wizard magic and it's all the same man you're just manipulating symbols you know oh here they're even making a claim about where it is p rra so they're saying actually that huh let's test that so i just wrote some code for this to get the spike lego protein from sars no module named data yeah cause we're just gonna restart and then of course for our spike glycoprotein we just do corona spike like approaching right so these are the two so they're saying it's a pra let's do some furin oh look at that cleavage site can i cleave this one can't cleave this one look at that quality man look at that quality you know this might have been an easy let's try to understand if this is like a known thing or did that just come from that one paper uh i don't like how all these papers are talking about in general the more papers are talking about cov2 i'm less interested why does like why do they even think these are the same thing why do they align it like that that doesn't look aligned to me all those symbols look wrong furin in text prra i don't know about that you know this is all why why do they think here we go so something like predicted the furan substrate and the location of fury and cleavage sites can be predicted by two bioinformatics methods see they name them stupid things so if i feed in the sequence can i uh what are these things prop prediction of pro protein oh this seems better a 20 residue recognition sequence motif oh is pi tau open source oh here we go official gene symbol i think i can get that um i need the gene name no this one is that a gene i don't know what a far file is but maybe okay back trio my friend were for chinese company and you know their big company like billion dollars and they'd write stuff in english occasionally and uh you know my friends from america like who speaks english like you know and you proofread it and you'd be like you know this isn't how you write things and then you know the big boss was kind of like no no no no no no and that's why things are released like that i know but don't we all think it's disgusting monetizing the human disaster disgusting how close are we to cracking it man let me tell you something about the ps3 you know the ps3 took me five weeks the iphone took me 12. um no and then like to really finish the ps3 took another like the ps3 was like a six month project the iphone was a three month project the first time um the jailbreaks were usually done in about a week but yeah i mean what this shit's going to take 12 weeks man what do you think we're going to find a vaccine tomorrow yeah we just got started you watch my online streams we put three days into this it's gonna take a while to hack the coronavirus guys no i mean if if coronope's vaccine is gonna work we'll get back to okay get back to that um you guys wait until you had corolla virus ratio of new stuff we needed to learn versus stuff i know to hack the ps3 when i did the first iphone i didn't know the difference between kernel and user space i didn't understand that the baseband was a separate processor um i knew what idle was but i never really used it before uh yeah it's in the fun folder right uh discover at least does ginger have a plug-in for bio can we write one of those were they sledded slave files can we write a slave file for bio yes see like i didn't know no i mean i learned it then but like uh i don't know but see i'll say something else too um george watsky i think phrased this well uh it's you see the words i say and they portray me in the nicest light if only you heard the typewriter chatter tap tap tapping through my mind at night so for every project i've succeeded at there's also been a lot that i've failed at you know i put a lot of time in my life into uh trying to find a collision in shaw one um like a lot of time like i put months into that and uh in no show one collection uh oh i worked on this stupid nokia phone for weeks and weeks and weeks i wrote a gpu hashcracker to to crack these uh these nokia hashes um i missed a stupid rsa exploit in that one that came out a few months later and then the gpu thing became a thing and then i used those gpus to my bitcoin and buy drugs but uh yeah so like not all the projects succeed and i don't know if this is going to be one of them that succeeds or fails but it'd be pretty cool you know don't you think i've been learning a lot of stuff which is really cool i really like learning and i'm going to uh so you guys if you don't know i'm part-time at common now i'm not at uh i'm not a comma full-time anymore we're profitable the company's going well um well you know this week this week's not so great but um for the most part we're profitable uh yeah so i've been you know i've been working on backspace worked on backspace a bit um i've been promoted to part-time it's true but yeah so i have some time i don't know and i i kind of like hanging out on stream and i kind of like talking it's it's nice uh so maybe i'll hang out on stream for the next uh a couple of days until i really have to focus on something and write some real code but i mean like also like you know where is this project going i mean i don't know we're we're learning first that's the the first step to any uh to exploiting any system is um i still do a lot of work at kama but you know it's just not uh it's not a full-time uh job anymore we're hiring too if any of you are interested um it's a cool place to work like i think that we're i think that it's like really on the track to solving self-driving cars i don't really i didn't really feel that way last year but the comment is working really well what am i trying to achieve well the first thing that you do whenever you're about to hack a system is you have to learn everything about it when i did the ps3 i had a wiki that documented everything on the ps3 um for the iphone i don't think i had a wiki yet i think i just duh like the cool thing about reverse engineering this is like wikipedia has when you're looking up something specific from the iphone for example there was a binary called bb updater um and bb updater was uh the the thing that updated the baseband oh man you know i think back i think back in like how long would it take to do that iphone unlocked today in no time at all um i worked at a i was an intern at spacex it's people work very hard there people are very motivated by the mission um oh just because of my skills about the iphone hi galactic thank you for subscribing a promoter that drives expression of the protein this what is this website it's like ipfs huh i would see ya that's cool she's a crypto coin oh it's good of them they actually have something can you see a coin 54 million cool do i think elon's overrated no uh i think i don't know why we got derailed on this topic but i think without him there wouldn't be a spacex and a tesla and when i think about what companies are actually doing anything today to push the envelope those are the first two that come to mind right google and facebook have metastasized i think elon's foundational science is physics he's a modernist and i think my foundational science is information theory and as disgusting of a term as it is i'm a postmodernist you know elon knows a lot of physics um doesn't know as much about you know like deep learning and stuff remember that time that you know this is why elon always claims that he's going to solve self-driving cars in a year that's the growth is exponential man i don't know boring companies the dumbest shit i i think boring company is uh like nerling's cool but he's not going to achieve what he claims with it um boring company now that what i'm not doing any security shit man we're doing in security now computer security is played out and you know overrun by losers today don't don't do that shit computer security look when i did it like 15 years ago it was cool like hacking was this like true um you're like reading fracking stuff today you're going to devry university and getting a degree in cyber security you know all right uh based on injecting dna that synthesizes spike i spelt synthesizers wrong so i'm just going to use expresses uh we learned what plasmids were that's spider beer video guys very cool build apis around corona solutions this seems stupid but we'll give it a try what i know a great api it's called csv a poly a site after the coding sequence an origin or replication and an antibiotic resistance genie there and they're in plasmids um it's cool how it works the spider beer video describes it basically you um only some of your bacteria are going to take up the plasmid right and then the bacteria replicate and they replicate the plasmid hopefully too but you're left with you know a really large percentage of bacteria that don't have the plasmid and how do you separate the ones that don't from the ones that do well your plasmid includes an antibiotic resistance gene you put that antibiotic in the solution and then you're left with only the good bacteria the spike protein sequence will need to be synthesized by a third party so the spike protein is this many amino acids maybe cobble together can you synthesize a whole plasmid like if i go to one of these gene synthesis services how does it does the dna just come in a vial oh they do cloning do they put it in a uh i mean there should be a service actually that can give me will be delivered dry in a circularized plasmid 5 000 base pairs all right so i get 5 000 base pairs um i mean all right well i'm wasting that many on the stupid spike protein and i hope i can fit that other stuff in you know we gotta we gotta run packers on our code man uh and then all right so what's well it's only gonna cost me like this is gonna cost me like four grand bros you think if i sent them you think if i actually sent these people like the coronavirus spike protein mixed with like a couple other plasmid ship that actually make it for me i don't mean to steal these people's idea but you know they're gonna do it well and i'm gonna do it shitty um and i feel like i can get this strand of e coli to do the replication for me yo sick bro we're making bacteria work for us we're not just killing them anymore you see it used to be we'd fight them and now we just kill them but in the future bacteria are going to work for us um there's a buffer overflow at the end of fda's there's a's at the end of everything apparently um i forget exactly why i think it's because whenever it's copied some of those a's fall off sometimes there's like a's at the end of your dna and eventually like the a's start to get eaten up and then you die yeah telomere that's it is it called a telomere compound structure region of repetitive nucleotides wait that doesn't look like a's wow this book's full of words that i don't know endo free giga prep kit oh good thing they don't have endotoxins in them wait which kit was that a giga prep kit wow should we start buying some of this stuff you think it'll get here we should try some simple stuff first you know when you start pwning stuff you don't start poning you know your first buffer overflows are in joke programs right so like yeah we make like you know glowing glowing yeast or whatever good compilers for this and stuff the spider beer guy seems like he was just sticking them together but i will be i will point out that i haven't seen that project actually get finished get a thermocycler and start doing pcr yeah all right let's buy a does thermocycler have a good recommendation genome compiler.com doesn't work gene.org why do you think this stream is better what changed ready to use viral vectors eh oh no it's prone to dimerization i definitely don't want that or do i is that a good thing oh no oh bad m kalama plasma sent in bacteria as agar stab go you ever remember those strep throat kids oh yeah like and then you rub it on the plate the doctor let me rub it on the plate once i thought it was cool well that was crazy that's what they did back in the day i'm sure they'd never show that to you now you know what i mean i i mean i don't know i've been to the doctor in a long time but like when i was a kid i go to the doctor and uh they'd want to test to see if i'd strep throat this was sick and they just they'd stick a swab down your throat and they'd uh rub it on an agar plate and then they put the agar plate in the in the heater uh and they had the quick test and the long test i think the long test they didn't like put it in the heater or something because some of them like died by heat or something and then they would just look at it and be like oh yeah those bacterias we're gonna prescribers from amoxicillins this ad gene set is amazing for learning these methods oh if i'm conducting coronavirus research they'll prioritize my order that's nice of them i don't think they give you adderall for strep throat virus of the day oh so cool it's got a lot of stuff in it how many base pairs is that is that base pairs or is that amino acid it's probably base parasite six kilobases all viruses are expensive who are these people it's a non-profit plasma wow i can send them plasmids wait but i mean i guess okay these things i guess i think dna i guess is mad stable oh i can get crisper plasmids look at all the stuff i can buy it's an empty backbone man if i could just write the right code you know you have to contact specific labs i mean they'll check my credentials what do you mean credentials what are my credentials create an account i'm in the united states uh academic i'd say uh oh type in institution hmm huh comma ah um no we can i'm sure we can set up and what do you mean by an institution man what's an institution do they have do i have a description of what it is do i need to buy a thermocycler first and then put it in a thing and put a little sign over it and say you know what should we name it guys yeah yeah no i'm not coming as an institution ordering how do i create an account what is an mta uh they still make it clear to me like what is a lab verifying the status of your organization yeah yeah you know i see i say um yeah we'll just because we could set up and set up an organization exactly yeah i can a lab is a place where i conduct welcome to welcome to my my lab um we conduct experiments for research here uh now see that's what sucks about bio man i don't know why i'm looking at my first food here is there a lime should we eat a lime wine was delicious line this onion is sad can you eat onion potato you guys see the waffle maker three chips i heard about sous-vide okay how do i sous-vide vrv exe thank you for subscribing i used to have a vacuum sealer i used to smuggle weed into burning man and then i got my car searched in utah i didn't have any weed some bullshit that i got searched they found my vacuum sealer cops like what do you use this for if i'd known about sous vide i would have said sous vide there we go um but i don't have a vacuum sealer anymore oh yo guys no real talk though i bought something today okay if you do get coronavirus important to have how am i doing oh oh yeah 99 that's right um yeah but i don't have thermometer unfortunately my lab is very under-equipped uh so tomorrow i gotta wake up at 7 00 a.m and go to rite aid and stand in line to make sure i get one of the seven thermometers and the thermometer rations um no my oxygen is 99 it's good now it's percents bro yeah if that goes below yeah if that goes below uh 95 it's time to start worrying um i mean the other thing that i don't have in my house that i'd like to have okay so it seems like there's like four stages to coronavirus there's the asymptomatic stage uh some people never get past that there's the symptoms but they're flu-like and manageable and your pulse oximeter won't go below um you know it won't go below 95. if it does go below 95 you need oxygen uh and then if the oxygen stops working you need a ventilator i'm not going to go so crazy as to buy a ventilator but if i could buy oxygen i wouldn't mind it um i mean this is not like four states it's not stages but it's like you know how far the virus can progress in each person right the oxygen balloons no like i was looking this up it's oxygen concentrator if you get coronavirus you think you're gonna die you're probably not gonna die bro you might but it's unlikely i know the demographics of my stream oh yeah at lunch at work today we were like uh you know this this this uh it seems to affect men more than women you know more men are getting infected with than women and then you realize that the reason for this is probably because men don't wash their hands nearly as well as women you're 95 well okay maybe you're gonna die you're a cobalt programmer ah i mean this is the thing right uh treatment uh low blood oxygen level oh here we go i know if i buy an oxygen machine i'm just going to use it all the time liquid oxygen tank should i get one oh damn have a fire extinguisher close by i'm sure they're all sold out wow that i was looking at those are just the batteries but here seven liter do you hook this thing up with a tube or can i just have more oxygen in my house i kinda want one of these oh no no what else do they sell i can't man i can't you want to buy an oxygen machine or you want to buy a mobile wireless charger a whistling catalyst with shitty okay maybe these aren't the guys we want to buy an oxygen machine from it'll be here in may after everyone dies [Laughter] recreational wait [Laughter] yo man is that nitrous nah bro it's oxygen you want to hit wait i mean honestly like i want one of these not just to save me from coronavirus but like it delivers air through a sub headset well you carry on working so you can say goodbye to coffee jitters and unplanned naps is breathing oxygen bad for you i went to one of those oxygen bars once when i was hung over in vegas it was pretty nice don't they don't one of the ways like the cyclist guys cheat is they uh wait no no no no no no no they'll sell anything to people what's this no it's sold out everyone had the same idea they bought all the oxygen oh one new oxygen march 27th that's not that far away let me see if i'm logged into my amazon on this other browser yes i am you can remove those proceed to checkout whenever it gets here we now have 20 worth of oxygen showing up oh wait no it's not going to show up till april or may never mind cancel order no no i'm not waiting for april 27 to may 6th i'm out item would not arrive on time all right this really got derailed i think i think yeah i think i think we're gonna call it a night um wow 666 dollars uh yeah i think we're gonna call it a night thank you all for watching tonight's stream uh what did we do tonight well let's make sure that what do we do tonight we went over some some curves we made a little bit of progress in reverse engineering we went on some tangents about oxygen yeah we didn't really do that much tonight um maybe we'll stream tomorrow no promises for stream tomorrow the first stream starts the strongest and then the streams kind of fall off i feel um i'm kind of tired i don't know why i'm tired fatigued man i have coronavirus you know do i like jazz music no who do i crack pile solver all right we'll do we'll do three minute q a who's being racist no racism in my stream that's right do i have plans to develop agi yeah maybe we'll get to it after chronovirus um fireflies man oh that's a good song would i use neural link as a first adopter hell no how do i manage my passwords i'm not going to tell you that how did you get into programming and how do i improve so fast let me tell you i've been programming since i was five i don't know if you call 25 years fast but um is our company thinking about expanding into bioinformatics no comet ai solves self-driving cars me personally i'm gonna start a buyer lab and then buy things from gene bank or whatever those things were um no well use red or blue switches i got the toe brake capacitive so we never talk about keyboards on here yes i've heard about rocket league i played rocket league do you have asperger's asperger's uh i don't know man you tell me what's my first program it printed out like pp and poop and stuff and i thought it was funny i was like four um don't hit you know whenever people ask about adderall because i feel like i talk about it all the time can can all you guys in the chat like just respond to the adderall people with my usual spiel on adderall how are you as an intern give me a job at common ai or you want to be an intern in the bio lab well the bio lab doesn't have any funding so sorry about that comment that does though best way to learn computational linear algebra what do you mean by computational linear algebra i mean like deep learning why is elon saying corona is a joke i don't think he said that i think he said coronavirus panic is dumb i'm like yeah coronavirus panic is dumb panic is dumb man you know like like like if you're referring to those people who are like hoarding toilet paper and stuff like yeah that's dumb as shit man toilet paper is not even an essential good off the top of your head recital line of code you'll always remember int main parentheses into arc c char arc v char star rv little thingies clothespins do i still meditate yeah i mentioned yesterday um no don't be smoking these days man coronavirus is out there someone really psyched me out about that if everyone's gonna buy toilet paper i'm not gonna be the idiot that does not that's a good point uh thoughts on unpaid internships didn't obama make them illegal oh i gotta write a bot do i have enough toilet paper i'm not gonna tell you man um i'm motivated about the future of comma yeah man thoughts on you getting mod low attacking is too commercialized nowadays it's true but you know what's not commercialized bioman there's a whole wave of bio that's just gonna be taken out from underneath these shitty medical organizations you know think about it man yeah i was going to use an example of something but i shouldn't talk about that but the uh the things that the open source world can do and can do so quickly if everybody at home had dna printers uh i mean we probably would have died from someone releasing something terrible but you know we also would probably uh have a vaccine by now right just imagine how many people at home would be willing if they had printers to just experiment on themselves and like try a whole bunch of different things you know like just print out plasmids print out plasmids print out plasmids inject them see what kind of response you get um it would go horribly for some people but very quickly we'd figure out what works and what doesn't you know universal health care you mean the government being in charge man what is the government in charge of that's good again don't make me bring that graph up again but you find the things the government's involved in like education and healthcare are terrible and things that the government really has no say over at all like tvs are awesome and things like cars and housing are somewhat in the middle because the government has some say over them software is also software's also gotten incredible fire departments that's true though you do want the government involved with fire departments because do i do i give this example it's probably one of the things i talk about if you had a for-profit fire department putting out fires isn't that hard there aren't even that many fires i mean you know they'd set up as a consulting service to prevent fires but eventually really they're gonna have to get growth you know they're going to show their quarter-over-quarter growth of the number of fires they put out and there's just not going to be enough fires to go around so you're going to get a skunk works division and this is just what the incentive say you're going to get a skunk works division the arson division right i mean you know they don't tell the rest of the company but they start the fires fire department goes puts them out and growth goes up right remember the episode in silicon valley where they get the the click farm you know faking all the clicks it's arson division yeah no health insurance is not exactly the same you think they're going to make people sick i think that's i mean that's a little further fetched than uh there's a lot of people there's a whole lot more people out there who will do uh property damage like things right and look here's how the arson division would work right the arson division is not going to go around burning random people's houses down they're not going to be very popular they're going to find somebody who has a nice fire insurance policy and burn their house down right there's a whole lot more people out there willing to do financial fraud than actually like do harm to another person food deserts already make people sick i've never was there where's these food deserts man people's always talking about this you know there's sleep paralysis no favorite conspiracy theory infinity is a scam i'm a finitist keep it up they help us all stay calm thank you thank you they kind of helped me stay calm too it's nice and calming um we're destroying people's lives in the global economy for less deaths than the annual flu well so here's the problem with that uh you know and i yeah i want to say like like in my personal life com ai is still shipping out products we're shipping out products on schedule um i think that it's important while being safe from coronavirus to keep the economy going as best you can um i think that yeah i mean i think that the economy is really important but right now it's less deaths than the annual flow if if this thing spreads to a huge percentage of the population it's going to be a lot more deaths than the flow right you can't just say like right now it hasn't right right let's say i i uh i have a car that one out of ten cars uh you know uh randomly jerks the steering wheel and drives off a bridge right and let's say i've sold 100 of those cars you could be like well yeah but i only you know it only killed 10 people man you know toyota cars killed like 12 000. well yeah but you know you sold as many cars as toyota you see the problem the mortality rate is significantly higher in the flow taylor and camera feuding oh is this is this more of that because kanye yo i made that bitch famous uh you an anarcho-capitalist i don't know what that is man you know my thoughts on anarchy is p equal to np i don't think so but i do think that p equals uh bpp uh sorry bqp uh b also equals bpp but i think that one more people accept um don't don't p values trigger me don't get me started on p values man p equals fc squared how do i feel about ethereum 2.0 i don't know i'm about to have an opinion we'll win the next election no no i'm not in the politics man i think joe biden has dementia and then like america is going to have to choose between you know a man with dementia and trump and like well we'll see what we choose who do i think is gonna win i think whatever predict it says love your call i'm glad you let me call uh bqp times bqp equals bqp not bqp i don't know z distribution you can go to any doctor that you willing to wait for meaning you don't have to go within the network for free when do i think coronavirus will be last week's news um i mean what's going to happen that's bigger than coronavirus thank you i should i try to i feel calm tonight i didn't feel so calm yesterday i do not wear crocs no um i mean when was 9 11 last week's news right i mean at some point it was i don't really believe that bch is the real bitcoin i think it's a funny meme i don't think there's any such thing as the real bitcoin that's why it's funny 911 was last week's news like seven weeks after it happened i don't know about that um you know i was there i lived uh i lived half an hour from from the world trade center um and they say something from school early and you go home and we didn't have a cable tv back then we had antenna tv you turned the tv on and channel two works but 4 5 7 9 11 and 13 don't you know why george hawts don't don't what how's the stock market crash effectively to be honest like yeah i have less money it's all fake anyway you know uh if we solved cancer or heart disease do you think coronavirus would be a real threat no cancer and heart disease are a much bigger deal than coronavirus oh if i had you know if i get coronavirus i'm not that scared if i get cancer shit man i'm not talking shit about 911 men i'm not talking shit what do you think i'm talking shit man cancer can't be transmitted yeah no i don't know so i mean i think i think uh coming back to the original question like uh i i think that that story i told not talking shit i'm more saying like that was just what made 911 extremely real for me i mean it's weird you know small things like that uh am i a virgin uh am i as scared of ai's elon i don't think so no i watched the first episode of the bill gates thing where do i see myself in 15 years i don't know um no but i think i've got something to think about like when will this be old news people are going to talk about it for a while there's a lot of there's a lot of uh you'll see like the volatility index of the stock market's extremely high um check this out i can probably google let's go yeah now just give me that but for longer if someone wants to link you guys do a great job with us oh yeah this is cool huh why is that lit up that's the recession that's coronavirus well it's good that volatility is going down wow what happened then yeah that's i mean that's the financial crash from this is cool i don't think brexit was actually that big a deal um i also don't think trump's election was that big a deal does the government shut down honestly does the government do anything besides take our money that's kind of how i feel i mean if the federal government shut down i mean the russia government shut down and it was kind of okay um so yeah i don't want to give the power back to the states yeah that sounds like something do you think corona will dip off on us for us to have a good 420 no these i think these next two months are going to be rough i will see it might taper out but the problem is if it tapers out and we if it tapers out because of the quarantine measures as soon as we let up on the quarantine measures it's just going to go up again um do you think human response to coronavirus would be adequate enough when faced with an actual viral threat i think this is definitely an actual viral threat i'm not sure i'm not sure what more you expect to be fair if this thing had like a 50 death rate i think everyone would respond way more extremely and actually i think if it had a 50 death rate it never would have spread right like you think about it like that you think about it once things become too deadly humanity will go to any extreme to stop them but you know my age range corona 0.2 chance of killing me all right you know how scared am i if i get the disease a one month incubation 50 percent yeah we would be under marshall on a minute um where do i think it's gonna stop i think give it two more months and we're gonna have a really good i i think i think even in a month we're going to have a good idea of an answer to that question um oh yeah i should play those games pandemic and plague and stuff what human language is [Music] no hablo rappy though i'm just like uh who's that guy marco rubio or plague.com no no that's not that's not that's not the game is that the game like pandemic is the game this is good with the reviews if it's banned in china it's got to be good overwhelmingly positive very positive or i'll do it um i don't wanna show you guys my steam account shit uh let's do it over here let's play some play game it's gonna take a long time to download plaguing evolved yes yes um add to cart purchase for myself you must agree to the steam yeah yeah yeah yeah sweet install content all right we're downloading plague yo look we're playing games would like to receive keystrokes what no all right my mouse froze dimension there we go oh create my very own fake news story all right let's go um wait let me first see can i make the resolution bigger [Music] i have to unlock the virus okay we'll play it with bacteria oh damn this is like um all right all right fine i'm a new player let's play it on casual name my plane sars no it's a bacteria we gotta name it a bacteria polio v2 let's go hang on i'll make me smaller so you guys can see the whole game casual is really easy is it too easy select the country to begin my plague well we know what country we're choosing let's go uh okay oh good i love that they haven't grounded the planes yet oh all right what can i do oh look at those hot spots oh no no no i didn't mean to click there i'm gonna minimize this so it doesn't keep doing this okay well good right i think we got some spread to mongolia you control the plague indirectly by evolving it here we go all right all right [Music] blood to blood oh poor musicians oh insects oh that sounds nice yeah oh yeah if i just increase the infectivity we'll get everybody severity doesn't even have to be too bad i don't think we want severity if our goals is our goals just to infect everyone or to kill them all [Music] trump's playing this at all [Music] you're on the wrong team bro [Music] okay why does this affect me [Music] let's see what the symptoms are oh yeah i like that yeah yeah yeah let's make people unable to sleep [Music] oh hypoxia abilities [Music] it is bacterial we should really spend some time on antibiotic resistance yeah business as usual no we gotta shut this down i can't believe they banned this in china i love that we live in a free country guys upper right oh i can increase the speed oh i see oh people are being infected faster and faster okay wait does time stop when i do that now we got we got to make it more effective [Music] yeah sweet oh yeah spread to russia look at that that's a lot of infected people it's not killing anybody though oh no aid initiative there we go yeah that'll get those poor countries oh yeah sounds annoying oh yeah oh more infectious from tv all right we gotta slow this down people are gonna start to respond to this fast now world menu okay all right that looks like a lot of the world that's pretty good sweet they haven't grounded anything yet oh yeah you got on a plane that was a dumb choice [Music] birds insects oh air that sounds good um that's a good point we need 12 okay we got to get a few more and then we're going to buy that yeah that's right oh look we're seeing all the harmless disease oh harmless you say oh perfect so so that sounds nice i mean i guess my question kind of is if i then change the symptoms research priority law oh good perfect there's not enough dead people though we gotta increase the number of dead people how do we do that [Music] oh no they shut down the borders fatal source of gangrene yeah but if people die aren't they gonna do more research oh oh yeah what else makes it more deadly oh yeah that's good so foreign people are looking for a cure now let's pause while we figure out how to make sure that doesn't happen yeah that's right slow down your research [Music] when are they gonna find a cure oh that doesn't seem good [Music] all right we haven't gotten africa yet let's get africa [Music] what's gonna make it spread in africa livestock yeah [Music] oh insects that always gets them in africa [Music] extraordinary mutation patterns what was morocco hard algeria hmm it's hot there i think that's gg there's definitely a way to lose this game i just played it on easy mode well that's a brutal game so glad i don't live in china where we have you know we're in america where we have free speech and we can play games like that wait i haven't gotten everybody yet um i think we need more symptoms yeah that one's good that one's good those last million aren't going to find the cure so pretty cool play on the hardest all right all right all right play hard mode alright i got you all right you know what yeah yeah that's that's a good idea well we'll end the stream on a hopeful note where i lose that that's that's a good idea plagues don't always win sometime humanity triumphs then there's a new mode to save the world by popular demand oh and normal or higher to unlock let's see the scenarios huh we'll just play on hard covid 69. all right well we'll start this one in in the usa all right i like it surviving in water too infected can i lose before they even like spread it at all three sweet [Music] hmm you'll get them on birds [Music] so [Music] top-notch dynamite world of pc and i think the first idea is to spend on infectivity are a bunch of people streaming this oh all right rats i'm sold yeah get the city dwellers man oh coughing symptoms sweet level two hype train yo get this hype train going let's win mega brutal this pathogen kind of sucks why is everybody like washing their hands all right should we upgrade for double rats birds no no let's get birds 15 dna points my this game is actually being extremely generous to me this thing would have died out a long time ago i guess it's a bacteria and you can have like a deep reservoir of it or something what do i do [Music] it's the problem with time you know okay we gotta get the birds but it's not even spreading in the u.s you know why don't i pick um a less developed country perfect so we still have the same five people so is this just just brutal just take forever it's only about five people strong dry winds i need more transmission yeah yeah well i don't i only have four dna points upgrade abilities i don't think so any more transmission i think i already upgraded a lot of these you can try livestock or we can try to get one of these [Music] where are we right now i mean those are those are fairly rural areas of america i don't know if that's accurate guys this disease is boring [Music] yeah we're gaming no 3400 maybe in ethiopia from the tsunami oh the tsunami killed him well i'm losing to a tsunami all right all right eight people all right no six people never mind mexico that's a good strategy i like the mexico strategy what will spread it to mexico all right let's save up for that insect one 24. mexico closed its borders over 10 diseases no they didn't oh you mean irl yeah irl i think they did the irony so do we save up for the super rats fudge the death toll numbers yeah i can devolve but i barely get any points for it it seems like you just gotta like be patient wait for those things to pop up no i can't can i put rats i don't think i can put rats can i [Music] so bird seems like a good deal me 22. oh devolve all symptoms okay wait it costs money to devolve i don't even get it back i just spent money on devolving not all the ones that gave you infectivity you get small amounts back no it looks like i just spent things and now i have less infectivity you know what ultra brutal winds guys ultra brutal winds ah you know humanity wins that's that's a pleasant note with which to end tonight's stream on uh maybe i'll stream again tomorrow but probably not i probably will stream again wednesday no no more q a really did q a it's bedtime good night everybody thank you all for watching we are gaming channel our christian channel we spread love and everybody subscribe to me so we can spread money and by spread money i mean spread money you know what i mean i check my twitch i'm like damn i'm making money i should stream more but then i remember that i don't do it for the money i do it for the love goodnight everybody