The Excretory System: From Your Heart to the Toilet - CrashCourse Biology #29

Key Takeaways

one of the coolest and most important things that our bodies do is maintain this thing called homeostasis it's a regulation of a stable internal environment no matter where we are or what we're doing after all we put our body through a lot every single day we're always adding food and liquid and chemicals and we're constantly changing temperature and our levels activities but our bodies can roll with it it's like no big deal for them all of our organ systems have some hand in maintaining homeostasis I mean it's basically the thing that makes us not dead but the excretory system aka the urinary system which includes the kidneys the uror the bladder and the urethra is the star quarterback of the homeostasis team that's because your excretory system is responsible for maintaining the right levels of water and dissolved substances in your body this is called osmo regulation and it's how our bodies get rid of the stuff we don't need like the byproducts of metabolizing food while also making sure that we don't get dehydrated it's the body's greatest Balancing Act and your body is doing it right now and all of the time as long as you're not dead [Music] as with other organ systems we've talked about not all excretory systems in the animal kingdom are created equal different animals excrete wastes different ways based on their evolutionary history what environments they live in and what their hobbies and interests are these factors all influence how an animal regulates water and most metabolic waste needs to be dissolved in water in order to be excreted the problem is a main byproduct of metabolizing food is ammonia which comes from breaking down proteins and it's pretty toxic so depending on how much water is available to an animal and how easy it is for the animal to Lug a bunch of water around inside it animals convert this ammonia into either Ura or uric acid mammals like us as well as amphibians and some marine animals like sharks and sea turtles convert ammonia into UA a compound made from combining ammonia and carbon dioxide in their livers the advantage of Ura is it's very low toxicity it can hang out in your circulatory systems for a while with no ill effects but you have to have some extra water available to dissolve it and get rid of it this isn't such a tall order really I mean peeing isn't a huge inconvenience I mean is it it's not for me anyway well it would be though if you were a bird or an insect or a lizard living in the desert animals that have to be light enough to fly or don't have a bunch of spare water hanging around convert ammonia into uric acid which can be exed as kind of paste so not a lot of water is needed you've seen bird poop if you haven't taken a close look next time do that just look the white stuff in the bird droppings is actually the uric acid EP p and the brown stuff is the poop so now that we've established what is and what is not bird poop let's get down to the Pras tax of how humans get all of this Ura out of our blood and into our toilets the expiratory system starts with the kidneys the organs that do all the heavy lifting from maintaining those levels of water and dissolved materials in our bodies to controlling our blood pressure and even though they do an amazing job I'm Not Bow mathing your kidneys here the way that they do it is frankly a little bit janky and inefficient to start out by filtering a bunch of fluid and the stuff dissolved in the fluid out of your blood and then uh they basically reabsorb 99% of it back before sending that 1% on its way in the form of urine seriously 99% gets reabsorbed on an average day your kidneys filter out about 180 L of fluid from your blood but only 1.5 L of that ends up getting peed out so most of your excretory system isn't dedicated to excreting it's dedicated to reabsorbing but the system works obviously I'm still alive so we can't argue with that now it is time to get into the nitty-gritty details of how your kidneys do all this and it's pretty cool but there's a lots of weird words so get ready your kidneys do all this work using a network of tiny filtering structures called nephrons each one of your mango siiz kidneys has about a million of them if you were don't do this but if you were to unravel all of your nephrons and put them end to end they would stretch over 80 km this is where all the crazy action happens so to understand how they work we're just going to follow the flow from your heart to the toilet blood from the heart enters the kidneys through renal arteries and just so you know whenever you hear the word renal it means we're dealing with kidney stuff as the blood enters it's forced into a system of tiny capillaries until it enters a tangle of porous capillaries called the glomerulus this is the starting point for a single nefron the pressure in the Glarus is high enough that it squeezes some of the fluid out of the blood blood about 20% of it and into a cuplike sack called the Bowman's capsule the stuff that gets squeezed out is no longer blood it is now called filtrate it's made up of water Ura some smaller ions and molecules like sodium glucose and amino acids the bigger stuff in your blood like the red blood cells and the larger proteins they don't get filtered now the filtrate is ready to be processed from the Bowman's capsule it flows into a twisted tube called the proximal convoluted tubule which means the tube near the beginning and that is all windy why are we so bad at naming things anyway it's this is the first of two convoluted tubules in the nefron and these along with other tubules we're talking about are where the osmo regulation takes place with all kinds of tricked out specialized pumps and other kinds of active and passive transport they reabsorb water and dissolve materials to create whatever balance your body needs at the time in the proximal tubule it's mainly organic solutes in the filtrate that are reabsorbed like glucose and amino acids and other important stuff that you want to have hang on to but it also helps to recapture some sodium and potassium and water that we're going to want later from here the filtrate enters the loop of Henley which is a long hair pin shaped tubule that passes through the two main layers of the kidney the outermost layer is the renal cortex that's where the glomerulus and the Bowman's capsule and both convoluted tubules are and the layer beneath that is the renal medulla which is the center of the kidney cortex by the way is Latin for tree bark so whenever you see it in biology you know that it's the outside of something Mulla on the other hand meaning marrow or pith so you know that it's the inside just to help you remember this stuff but before we take a tour of this amazing loop I have to do a couple of things first go pee cuz this is you know and second a biography so I'll be right back the loop of Henley was discovered by 19th century German physician and anatomist Friedrich Gustaf Jacob heny and I'm pretty sure he was just one of those guys that you can't gross out cuz he spent most of his career dissecting kidneys and eyeballs and brains and also seemed to be a huge fan of mucus and pus he was by far the most important anatomist of his time his three volume Handbook of systematic human anatomy was recognized as the definitive Anatomy textbook of its day and was famous for its Exquisite attention to detail and its intricate even beautiful illustrations not only did Henley discover the loop of Henley arguably the Lynch pin of kidney function in mammals he was also an early adopter of the wildly unpopular germ theory of disease his student Robert kooch is considered to be one of the founders of microbiology and the two work together to formulate the Henley Coke postulates which today Remain the four conditions that must be met to establish a causal relationship between a microbe and a disease Henley taught the world so much about the human body that there are right now in you no fewer than nine features that bear his name from the Henley's fissures between the muscle fibers of your heart to the crypts of Henley which are microscopic pockets in the whites of your eyes also the name of my Cradle of Filth cover band all right so review time we've squeezed some filtrate out of the blood and reabsorbed some of the important organic molecules we want to keep but most of the reabsorption action happens here in the loop of Henley which does three really important things one it extracts most of the water that we need from the filtrate as it travels down to the medulla two it pumps out the salt that we want to keep on the way back up to the cortex and three the process of doing all that it makes the medulla hypertonic or super salty relative to the filtrate creating a concentration gradient that will allow the medulla to draw out even more water one last time from the filtrate before the final Journey to the toilet begins it's complicated and again kind of janky but it's what allows us mammals to create urine that's as concentrated as necessary using only the amount of water that our bodies can spare at the time so first filtrate starts going down the loop and the thing to know here is that the membrane is highly permeable to water not so much to salt or anything else mainly water now compared to the filtrate the tissue of the medulla is already pretty salty and as the filtrate processes the surrounding tissue becomes increasingly hypertonic the farther down you go the saltier it gets so applying everything that we've learned about osmosis you know that as the filtrate moves along it loses more and more water through the membrane by the time the filtrate gets to the bottom of the loop it's highly concentrated and now the filtrate enters the ascending end of the loop and here it's basically the same but in reverse the membrane is not permeable to water and instead it's lined with channels that transport ions like sodium potassium and chlorine and because the filtrate is so concentrated now it's actually hypertonic compared to the fluid outside in the medulla so as it ascends huge amounts of salt start flowing out of the filtrate which makes the renal medulla really really really salty the salty medulla also creates a concentration gradient between the medulla and the filtrate which we're going to need and the final step of pee making But First Once the filtrate is back up in the cortex and out of the loop it enters the second of our convoluted two tubules called the distal convoluted tubule or farther away curly tube while the first tubule worked mostly in the reabsorbing of organic compounds in the filtrate here the focus is on regulating levels of potassium sodium and calcium this work is mainly done by pumps and hormones that regulate the reabsorption process by the time it's done we have finally taken everything we want to keep out of the filtrate so now it's mainly just excess water Ura and other metabolic waste this stuff all gets dumped into collect duct that channel it back down to the center of the kidney the medulla and remember the medulla is super salty right now more hormones kick in that tell the collecting ducts how porous to make their membranes if the membranes are made very porous more water is absorbed into the medulla which makes the urine yes we can start calling it urine now even more concentrated and here's a fun fact if you've ever had one drink too many you might have noticed that you start to pee a lot and your pee is clear that's because alcohol interferes with these hormones especially one called called anti-diuretic hormone which tells the collecting ducts to be very porous so that you reabsorb most of the water with those hormones all confused and out of commission you just start peeing out all kinds of water which also means you're getting dehydrated which means you're efficiently on a one-way trip to hangover City so now you know why that happens now at this point the urine leaves both kidneys and flows down to the urinary bladder by tubes called urits once in the bladder the urine just sits around waiting for us to decide when it's time to find a bathroom and when that time comes a little sphincter muscle relaxes and releases the urine from the bladder into a tube called the urethra which empties out wherever you point it so that's how your excitory system works and that's basically how it works for most mammals although some modifications are made based on again where they live and what they do for instance kangaroo rats which are tiny and adorable and live in the desert have the most concentrated urine of any animal anywhere because it can't spare the water so it has a very very long Loop of Henley that reabsorbs most of the water water from the filtrate on the other end of the spectrum we have the Beavers who have very short Loops of Henley because they're like water reabsorption smarter reabsorption do you see what I do all day so now you know the true origins of P thank you for coming to learn with us here at crash course biology we hope that you learn something you can go to youtube.com/ course And subscribe for more biology and history videos thanks to everyone who helped put this video together there's a table of contents over there you can click on and review stuff that you didn't get and of course if you have any questions for us you can leave them in the comments or on Facebook or Twitter and we will endeavor to answer goodbye