Why Do Scientists Keep Finding New Organs?

Seeker · Intermediate ·📄 Research Papers Explained ·7y ago

Key Takeaways

The discovery of the interstitial tissue as a potential new organ and its role in the human body, including its function as a shock absorber and its connection to the lymphatic system, is discussed using confocal laser endo microscopy and traditional slice and stain methods.

Full Transcript

did you know that you have a whole new organ I know it just popped up overnight I don't think I felt mine growing in did you no I'm just kidding the structure was actually always there but we're only just now recognizing what it is and how it really works and it's a pretty big deal it changes the way we see not only our bodies and how they work but also a whole host of important diseases but does that really make it a new organ and organize a group of tissues that perform a specific function there's a thing in our body called the interstitial also known as the interstitial space which is a layer of tissue we've known about for a long time it sits beneath our skin surrounding all of our organs and arteries and veins and muscles blanketing them on the inside just like our skin covers the outside of our body but a few months ago researchers were looking at a patient's bile duct for signs of cancer when they saw something in the interstitial that didn't match up with any known human anatomy see the way we typically study human tissues in a lab is to take an extremely thin slice and look at it on a slide under a microscope maybe dying at different colors to enable us to see certain structures but doing this removes all the fluids from the tissue sample and this means we've been missing something big up until now we've thought that the interstitial was just plain old connective tissue we have connective tissue all over our bodies connecting our bones to one another connecting our muscles to our bones and generally just kind of holding us together it's important but it's pretty ubiquitous and typically not very specialized but these researchers saw something new because they were looking at tissue samples in a new way using a technique called confocal laser endo microscopy they could see the true nature of the interest issue this visualization method uses a low powered laser to scan an area of the body and create a digital 3d reconstruction using this technique researchers could now observe a whole network of fluid-filled sacs structures that got drained and therefore essentially disappeared when we've looked at interstitial samples with the more traditional slice and sculpt method we've now observed that the interstitial is actually a complex network of interconnected fluid filled compartments supported by connective tissue proteins like collagen and elastin it may act as a shock absorber twisting and bending with our bodies as we move and keeping our organs in place keeping them from tearing or otherwise flopping or floating about in our is perhaps even more importantly the fluid in the inter system is connected to our lymphatic system draining to our lymph nodes and it may actually be a source of lymph which is huge because lymphatic fluid is an essential part of our immune system carrying cells that fight infection but it also plays a major role in the spread of cancer when cancer metastasizes it spreads from its tissue of origin to other parts of the body through the blood or the lymph so understanding the interstitial as a new key player in lymphatic system could give us a better understanding of cancer and why and how it spreads but the million-dollar question is the interstitial truly an organ no not yet at least for it to be classified as an organ it'll take lots of follow-up research and verification I mean the mesentery which we talked about last year still isn't an official organ so it takes some serious doing to get on that list really calling something an organ is mostly a semantic distinction it could help direct research toward this structure but the significance of this work is pretty independent of whether we call the interstitial a new organ or not this study not only revealed brand new information about the way our bodies work but also made us call into question the way we've been looking at them and last but not least this discovery has sparked conversation once again about what organs are and how we classify them and what counts as one a discussion that's constantly evolving in the scientific field I love that science is always changing and learning from itself so what else do you think we haven't known about our bodies this whole time let us know in the comments and make sure you subscribe to seeker to keep up with all the constantly evolving science news thanks for watching

Original Description

This long ignored connective tissue now serves a more important role and may act as a shock absorber, keeps our organs in place, and even plays a major role in the spread of cancer. But is it an organ? How Scientists Found a New Neuron Hiding in Our Brains - https://bit.ly/2zuc1pm Read More: Scientists found a ‘new organ,’ but it might not be what you’re expecting https://www.popsci.com/interstitium-new-human-organ-anatomy “Previously, researchers thought the interstitium was simply a layer of connective tissue. Connective tissue is absolutely not anything new. We’ve known about it—and how it functions—for a long time. Connective tissue typically has very few cells and instead is mostly constructed of various cartilage and other fibers that together form a strong structure that holds your organs in place or to connect one bone to another, or a muscle to a bone.” Structure and Distribution of an Unrecognized Interstitium in Human Tissues https://www.nature.com/articles/s41598-018-23062-6 “Confocal laser endomicroscopy (pCLE) provides real-time histologic imaging of human tissues at a depth of 60–70 μm during endoscopy. pCLE of the extrahepatic bile duct after fluorescein injection demonstrated a reticular pattern within fluorescein-filled sinuses that had no known anatomical correlate. Freezing biopsy tissue before fixation preserved the anatomy of this structure, demonstrating that it is part of the submucosa and a previously unappreciated fluid-filled interstitial space, draining to lymph nodes and supported by a complex network of thick collagen bundles.” Is the Interstitium Really a New Organ? https://www.the-scientist.com/daily-news/is-the-interstitium-really-a-new-organ-29893 “New reports have suggested that this interstitium could represent a widespread organ in the body, whose connections with the lymphatic system might be involved in cancer metastasis. While researchers not involved in the study agree that the interstitium likely plays diverse roles
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The interstitial tissue has been discovered as a potential new organ, playing a crucial role in the human body, including as a shock absorber and in the spread of cancer. This discovery was made possible by the use of confocal laser endo microscopy, which allows for a more detailed understanding of the tissue's structure and function.

Key Takeaways
  1. Understand the traditional methods of studying human tissues
  2. Learn about confocal laser endo microscopy and its applications
  3. Recognize the importance of the interstitial tissue in the human body
  4. Explore the connection between the interstitial tissue and the lymphatic system
  5. Consider the implications of this discovery on our understanding of cancer metastasis
💡 The discovery of the interstitial tissue as a potential new organ highlights the importance of continued scientific research and the need for new and innovative methods of studying the human body.

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