Google DeepMind's AlphaFold 2 explained! (Protein folding, AlphaFold 1, a glimpse into AlphaFold 2)
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In this video I walk you through what the protein folding problem is, I dig deep into the AlphaFold1 paper, and finally, I take a glimpse and I predict what AlphaFold2 may look like.
This thing is huge. Hopefully, it will accelerate the pace of solving the COVID-19 pandemic as well.
You'll learn about:
✔️ Recap of essential biology
✔️ What is the protein folding problem?
✔️ How does AlphaFold1 exactly work
✔️ How does AlphaFold2 probably work
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✅ DeepMind on AlphaFold2: https://deepmind.com/blog/article/alphafold-a-solution-to-a-50-year-old-grand-challenge-in-biology
✅ DeepMind on COVID-19: https://deepmind.com/research/open-source/computational-predictions-of-protein-structures-associated-with-COVID-19
2 more useful DeepMind blogs:
✅ https://deepmind.com/blog/article/AlphaFold-Using-AI-for-scientific-discovery
✅ https://deepmind.com/research/case-studies/alphafold
✅ What is protein? https://www.youtube.com/watch?v=wvTv8TqWC48&ab_channel=RCSBProteinDataBank
✅ How are proteins created? https://www.youtube.com/watch?v=gG7uCskUOrA&ab_channel=yourgenome
✅ Nature's blog on AlphaFold2: https://www.nature.com/articles/d41586-020-03348-4
✅ Christian Anfinsen's Nobel prize lecture: https://www.nobelprize.org/uploads/2018/06/anfinsen-lecture.pdf
✅ Charts for sequenced proteins: https://www.ebi.ac.uk/uniprot/TrEMBLstats
✅ PDB sequenced vs 3D structure found: https://www.rcsb.org/stats/growth/growth-released-structures
✅ AlphaFold1 paper: https://www.nature.com/articles/s41586-019-1923-7.epdf?author_access_token=Z_KaZKDqtKzbE7Wd5HtwI9RgN0jAjWel9jnR3ZoTv0MCcgAwHMgRx9mvLjNQdB2TlQQaa7l420UCtGo8vYQ39gg8lFWR9mAZtvsN_1PrccXfIbc6e-tGSgazNL_XdtQzn1PHfy21qdcxV7Pw-k3htw%3D%3D
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⌚️ Timetable:
00:00 Enter the AlphaFold2
03:40 Nobel prize winner Christian Anfinson, biology recap
05:50 Experimental methods (x-ray crystallography,
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Chapters (3)
Enter the AlphaFold2
3:40
Nobel prize winner Christian Anfinson, biology recap
5:50
Experimental methods (x-ray crystallography,
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Tutor Explanation
DeepCamp AI