TrialCalibre: A Fully Automated Causal Engine for RCT Benchmarking and Observational Trial Calibration

arXiv:2604.25832v1 Announce Type: new Abstract: Real-world evidence (RWE) studies that emulate target trials increasingly inform regulatory and clinical decisions, yet residual, hard-to-quantify biases still limit their credibility. The recently proposed BenchExCal framework addresses this challenge via a two-stage Benchmark, Expand, Calibrate process, which first compares an observational emulation against an existing randomized controlled trial (RCT), then uses observed divergence to calibrate