TrajOnco: a multi-agent framework for temporal reasoning over longitudinal EHR for multi-cancer early detection

arXiv:2604.10386v1 Announce Type: new Abstract: Accurate estimation of cancer risk from longitudinal electronic health records (EHRs) could support earlier detection and improved care, but modeling such complex patient trajectories remains challenging. We present TrajOnco, a training-free, multi-agent large language model (LLM) framework designed for scalable multi-cancer early detection. Using a chain-of-agents architecture with long-term memory, TrajOnco performs temporal reasoning over sequen