Simulation-based inference for rapid Bayesian parameter estimation in epidemiological models: a comparison with MCMC

arXiv:2606.27286v1 Announce Type: new Abstract: Mechanistic epidemiological models are widely used to support infectious disease forecasting and public-health decision making. Bayesian calibration of such models is commonly performed using Markov chain Monte Carlo (MCMC), which can become computationally expensive for high-dimensional nonlinear systems and repeated near-real-time analyses. Here, we investigate simulation-based inference (SBI) using neural posterior estimation as a scalable alter