Scalable High-Recall Constraint-Satisfaction-Based Information Retrieval for Clinical Trials Matching

arXiv:2604.08849v1 Announce Type: cross Abstract: Clinical trials are central to evidence-based medicine, yet many struggle to meet enrollment targets, despite the availability of over half a million trials listed on ClinicalTrials.gov, which attracts approximately two million users monthly. Existing retrieval techniques, largely based on keyword and embedding-similarity matching between patient profiles and eligibility criteria, often struggle with low recall, low precision, and limited interpr