PRISM: Perinuclear Ring-based Image Segmentation Method for Acute Lymphoblastic Leukemia Classification

arXiv:2605.12851v1 Announce Type: cross Abstract: Automated analysis of peripheral blood smears for Acute Lymphoblastic Leukemia (ALL) is hindered by low contrast and substantial variability in cytoplasmic appearance, which complicate conventional membrane-based segmentation. We found that many recent approaches rely on heavy neural architectures and extensive training, but still struggle to generalize across staining and acquisition variability. To address these limitations, we propose the Peri