Lightweight Retrieval-Augmented Generation and Large Language Model-Based Modeling for Scalable Patient-Trial Matching

📰 ArXiv cs.AI

Learn to improve patient-trial matching using lightweight retrieval-augmented generation and large language model-based modeling for scalable and efficient results

advanced Published 27 Apr 2026
Action Steps
  1. Apply retrieval-augmented generation to patient electronic health records (EHRs) to reduce computational costs
  2. Use large language models (LLMs) to model complex eligibility criteria
  3. Configure LLMs to process EHRs in a hierarchical manner to capture long-range dependencies
  4. Test the performance of the proposed approach on a patient-trial matching dataset
  5. Compare the results with traditional machine learning methods and full-document processing with LLMs
Who Needs to Know This

Data scientists and researchers working on patient-trial matching projects can benefit from this approach to improve scalability and computational efficiency

Key Insight

💡 Retrieval-augmented generation can reduce computational costs while maintaining accuracy in patient-trial matching

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🚀 Improve patient-trial matching with lightweight retrieval-augmented generation and LLM-based modeling! 📊

Key Takeaways

Learn to improve patient-trial matching using lightweight retrieval-augmented generation and large language model-based modeling for scalable and efficient results

Full Article

Title: Lightweight Retrieval-Augmented Generation and Large Language Model-Based Modeling for Scalable Patient-Trial Matching

Abstract:
arXiv:2604.22061v1 Announce Type: cross Abstract: Patient-trial matching requires reasoning over long, heterogeneous electronic health records (EHRs) and complex eligibility criteria, posing significant challenges for scalability, generalization, and computational efficiency. Existing approaches either rely on full-document processing with large language models (LLMs), which is computationally expensive, or use traditional machine learning methods that struggle to capture unstructured clinical n
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