FLAG: Foundation model representation with Latent diffusion Alignment via Graph for spatial gene expression prediction

arXiv:2605.18055v1 Announce Type: cross Abstract: Predicting spatial gene expression from routine H\&E enables large-scale molecular profiling, yet current models treat this as isolated pointwise tasks, thereby overlooking essential biological structures like gene coordination and spatial distribution. To preserve these relationships, we introduce \textbf{FLAG}, a diffusion-based framework that redefines this task as structured distribution modeling. At the same time, we identify the critical \t