EPC-3D-Diff: Equivariant Physics Consistent Conditional 3D Latent Diffusion for CBCT to CT Synthesis

arXiv:2605.20470v1 Announce Type: cross Abstract: Cone-beam CT (CBCT) is routinely acquired during radiotherapy for patient setup, but its quantitative reliability is degraded by scatter, noise, and reconstruction artifacts, limiting Hounsfield Unit (HU) accuracy. We propose EPC-3D-Diff, a novel conditional 3D latent diffusion framework for volumetric CBCT to CT synthesis that introduces a projection domain equivariance loss derived from acquisition physics. Unlike common image domain equivarian