CLIMB: Controllable Longitudinal Brain Image Generation using Mamba-based Latent Diffusion Model and Gaussian-aligned Autoencoder

arXiv:2604.15611v1 Announce Type: cross Abstract: Latent diffusion models have emerged as powerful generative models in medical imaging, enabling the synthesis of high quality brain magnetic resonance imaging scans. In particular, predicting the evolution of a patients brain can aid in early intervention, prognosis, and treatment planning. In this study, we introduce CLIMB, Controllable Longitudinal brain Image generation via state space based latent diffusion model, an advanced framework for mo